![]() Hydrochloric acid and/or sodium hydroxide may have been added for pH adjustment (5.0-7.5). Heparin Sodium Injection, USP (porcine), preservative free, is available as follows:Įach mL of the 1,000 Units per mL preparation contains: 1,000 USP Heparin Units (porcine) 9 mg sodium chloride Water for Injection q.s. Structure of Heparin Sodium (representative subunits): The potency is determined by a biological assay using a USP reference standard based on units of heparin activity per milligram. It is to be administered by intravenous or deep subcutaneous routes. Heparin Sodium Injection, USP is a sterile solution of heparin sodium derived from porcine intestinal mucosa, standardized for anticoagulant activity, in water for injection. In heparin sodium, the acidic protons of the sulfate units are partially replaced by sodium ions. Heparin is strongly acidic because of its content of covalently linked sulfate and carboxylic acid groups. These sugars are present in decreasing amounts, usually in the order (2)greater than (1)greater than (4)greater than (3)greater than (5), and are joined by glycosidic linkages, forming polymers of varying sizes. Although others may be present, the main sugars occurring in heparin are: (1) α-L-iduronic acid 2-sulfate, (2) 2-deoxy-2-sulfamino-α-D-glucose 6-sulfate, (3) ß-D-glucuronic acid, (4) 2-acetamido-2-deoxy-α-D-glucose and (5) α-L-iduronic acid. ![]() Heparin is a heterogeneous group of straight-chain anionic mucopolysaccharides, called glycosaminoglycans, having anticoagulant properties.
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